Maiese, Z. Chong, Yan Chen Shang, S. SIRT1 has broad biological effects that affect cellular metabolism as well as cellular survival and longevity that can impact both acute and chronic disease processes that involve neurodegenerative disease, diabetes mellitus, cardiovascular disease, and cancer. Given the intricate relationship SIRT1 holds with a host of signal transduction pathways ranging from transcription factors, such as forkhead, to cytokines and growth factors, such as erythropoietin, it becomes critical to elucidate the cellular pathways of SIRT1 to safely and effectively develop and translate novel avenues of treatment for multiple disease entities.
Corresponding author: Kenneth Maiese, MD, e-mail: wntin75 yahoo.
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Gheorghita, Cornelia Amalinei, Irina-Draga Caruntu The protein capsid L1 of the human papilloma virus HPV - a key factor in the cervical carcinogenesis - is considered, together with p16, EGFR and COX-2, a characteristic marker for the evaluation of the malignancy progression and prognostic, in terms of tumoral aggressiveness.
The purpose of the present study was to make a comparative assessment between the immunohistochemical pattern of p16, EGFR and COX-2 and immunochemical expression of L1 HPV capsid protein, in low grade and high-grade cervical squamous intraepithelial lesions, in order to determine the relationship of these tumoral markers with the infection status of HPV, and their practical applicability in patients diagnosis and follow-up. Immunochemical detection of L1 capsid protein, on cervico-vaginal smears, indicates an immune status induced by the HPV infection and may offer prognosis information, mainly in LSIL lesions.
Identifying molecular features for prostate cancer with Gleason 7 papilloma inside lip on microarray gene expression profiles Loredana Balacescu, O.
Balacescu, N. Crisan, B.
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Fetica, B. Meurice, Al. Irimie, N. Dragos, Ioana Berindan-Neagoe Prostate cancer represents the first leading cause of cancer among western male population, with different clinical behavior ranging from indolent to metastatic disease. Although many molecules and deregulated pathways are known, the molecular mechanisms involved in the development of prostate cancer are not fully understood.
The aim of this study was to explore the molecular variation underlying the prostate cancer, based on microarray analysis genoma hpv ad alto rischio bioinformatics approaches.
Normal and prostate cancer tissues were collected by macrodissection from prostatectomy pieces. All prostate cancer specimens used in our study were Gleason score 7. The bioinformatics and functional analysis were based on Limma and Ingenuity software.
The microarray analysis identified differentially expressed genes between prostate cancer and normal prostate, which were up- or down-regulated at least 2-fold.
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P-values were adjusted for multiple testing using Benjamini-Hochberg method with a false discovery rate of 0. These genes were analyzed with Ingenuity Pathway Analysis software and were established 23 genetic networks.
Our microarray results provide new information regarding the molecular networks in prostate cancer stratified as Gleason 7. These data highlighted gene expression profiles for better understanding of prostate cancer progression. Corresponding author: Ovidiu Balacescu, PhD, e-mail: obalacescu yahoo.
Data regarding the possible association between ischemic stroke and the polymorphism of methylenetetrahydropholate reductase MTHFR CT and AC are still conflictual. Aim: The study tried to assess the association of the two MTHFR polymorphisms with ischemic stroke in a series of patients from a unique hospital center. Materials and Methods: The study comprised a total of patients 67 with non-cardioembolic ischemic stroke diagnosed by computed tomography or magnetic resonance imaging and 60 control cases.
The method we used was reverse hybridization performed on peripheral blood for CT and AC polymorphisms. In all patients a careful clinical examination, laboratory analyses of cholesterol, glucose amount and triglycerides, as well as their medical history were available.
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Results: The mean age of stroke patients was No statistically significant correlations of the two genotypes with infarct localization and dimensions ant with other potential risk factors hypertension, lipids, diabetes mellitus were observed. However, they could be rather involved in hemorrhagic stroke, as seen in our control patients.
Further evaluation on larger series is mandatory since homocysteine activity related to MTHFR activity could be easily influenced by folate or cobalamin derivatives. Sonoelastography of breast lesions: a prospective study of cases with histopathological solitar logic Ioana Andreea Gheonea, Liliana Donoiu, D. Camen, Florina Carmen Popescu, Simona Bondari Background: Elastography is an imaging technique, which displays the hardness of soft tissue, by showing the behavior of tissue when subjected to mechanical stress.
The purpose of this study was to assess the role of ultrasound elastography in differential diagnosis of breast lesions.
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We introduced in this prospective study patients diagnosed with breast lesions between January and January The patients were examined in the supine position and a ductal exploration was made over the breast. The final diagnose was cytology FNA - fine needle aspirationhistology after excision or follow-up for six months. For assessment of ultrasound elastography role in differential diagnosis of breast lesions, we performed ROC analysis.
Results: The elasticity score for benign lesions was on average 1. The mean diameter of malignant lesions papilloma inside lip The most common histology of the benign nodules was fibroadenomas, cysts, and fibrocystic change.
Of the malignant nodules, the most common lesion was infiltrative ductal carcinoma. We obtained a sensitivity of Conclusions: Elastography is a method which can complement conventional ultrasound by improving the diagnostic performance. The introduction of ductal ultrasound combined with elastography increased the sensitivity and specificity, the radial technique allowing the precise localization of lesions regarding the breast gland.
Correlation between histopathological form and the degree of neuroendocrine differentiations in papilloma inside lip cancer Elena Viorica Bocan, O. Mederle, Simona Sarb, R. Papilloma inside lip, D. Agapie, M.
The aim of this study was to investigate the neuroendocrine component of the prostatic carcinoma, in relation to the histopathological form and the degree of differentiation. Biopsies were obtained through transurethral resection, from 82 patients with prostate cancer. In order to assess the histopathological form and the Gleason score, one section from each case was stained with Hematoxylin-Eosin. Additional sections were stained with chromogranin A. Cells positive for chromogranin A have been identified in all the cases, but a larger number than that registered in normal tissue has been noted in 59 patients In most of the cases, the neuroendocrine cells have been distributed in small groups among the neoplasic cells, and rarely isolated.
In two cases of small cell carcinoma most of the tumoral cells have been positive papilloma inside lip chromogranin A. In conclusion, the study of neuroendocrine differentiation in patients with prostatic carcinoma revealed hyperplasia of positive chromogranin A cells, in Neuroendocrine prostatic differentiation is papilloma inside lip with the advanced stage of evolution and possibly with the resistance to hormonal treatment. Renal subcapsular tertiary lymphoid aggregates in chronic kidney diseases E.
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Mandache, M. Penescu In the last decade, it has been accepted the formation of tertiary lymphoid organs in the renal parenchyma during inflammatory conditions. These organized cellular aggregates contain B- and T-lymphocytes, dendritic cells, surrounded by neo-lymphatic vessels.
They have been described in renal allografts, acute and chronic interstitial nephritis, IgA and membranous nephropathies.
The functional characteristics of these lymphoid nodules remained still under consideration. After investigating the renal biopsies of patients with primary and secondary nephropathies, we have selected 20 cases showing lymphoid-like cellular aggregates located just beneath the renal capsule and having papilloma inside lip contacts with this kidney envelope.
All of these cases also showed an associated medium sized lymphatic vessel. The ultrastructure of these nodules proved to contain more or less the same cellular composition: lymphocytes, dendritic cells, seldom plasma cells and macrophages.
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We consider these particular subcapsular lymphoid-like nodules to be tertiary lymphatic structures in close association with the perirenal lymphatics, and the first to develop in any type of inflammatory and autoimmune renal condition.
VEGF and his R1 and R2 receptors papilloma inside lip in mast cells of oral squamous cells carcinomas and their involvement in tumoral angiogenesis Raluca Ciurea, Cl.
Margaritescu, Cristiana Simionescu, A.